Get Advances in Immunology, Vol. 55 PDF

By Frank J. Dixon

ISBN-10: 0120224550

ISBN-13: 9780120224555

From the reports of earlier Volumes "Provides unrivalled worth in either educational and financial phrases and may be bought by means of demanding pressed librarians as an important precedence to be jealously defended." -JOURNAL OF scientific MICROBIOLOGY "Advances in Immunology needs to locate itself one of the such a lot energetic volumes within the libraries of our universities and institutions." -SCIENCE "A provocative and scholarly evaluate of research." -JOURNAL OF the yankee scientific organization "Deserves an everlasting position in biomedical libraries as an relief in learn and in teaching." -JOURNAL OF IMMUNOLOGIC equipment

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These results suggest that SCF may promote the survival or development of NK/LAK precursors in the thymus and may act synergistically with IL-2 in augmenting the cytotoxic effector function of these cells. , 1991). , 1991). , 1989) and others of which, such as TNFa, can have a negative effect on myeloid development. , 1991). By contrast, the megakaryocytic lineage was suppressed by the administration of anti-NK cell antibodies. Although the complex control mechanisms underlying these effects remain to be elucidated, the results suggest that NK cell activity may contribute to some of the hematological abnormalities expressed by Sl/SZd mice.

These findings illustrate that, when given in appropriate amounts, soluble forms of SCF can act as a multilineage hematopoietic growth factor in nonhuman primates in uiuo and can promote both the expansion of progenitor cell populations in the bone marrow and the appearance of markedly elevated numbers of these cells in the peripheral blood. Of course, many of the effects of SCF in uiuo may reflect, at least in part, its ability to act synergistically with other, endogenous growth factors. , 1993).

It had been shown by Levi-Schaffer et al. (1986) that coculture of immature mouse mast cells on 3T3 fibroblasts could induce the mast cells to acquire a more mature phenotype, including increased histamine content, induction of the ability to synthesize and store substantial amounts of heparin, and alteration of the histochemical characteristics of the cells. Furthermore, several lines of evidence indicated that the ability of fibroblasts to maintain mouse mast cell viability in vitro required an interaction between SCF 42 STEPHEN J.

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Advances in Immunology, Vol. 55 by Frank J. Dixon

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