New PDF release: Advances in Immunology, Vol. 38

By Frank J. Dlxon (Ed.)

ISBN-10: 0120224380

ISBN-13: 9780120224388

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MHC-RESTHICTED RECEPTOR ON T CELLS 21 Other experiments have supported the idea that a and p chains only contribute to T cell specificity. 10 which lack either the hybridoma-specific ci or p chain. These variants have lost the ability to recognize ovalbumin plus IAd. While not conclusive, these experiments again suggest that T cell specificity, at least in class 11-specific T cells, can be accounted for entirely by receptor a and (3 chains. The existence of y chain mRNA in cytotoxic T cell lines still leaves open the possibility that some other surface molecule may play the same as yet unsuspected role (see below).

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Iinmunol. 127, 596. Lancki, D. , Lorber, M. , Loken, M . , and Fitch, F. W. J. Exp. Med. 157, 921. , Ulberg, M . , and Wigzell, H. J . Exp. Med. 155, 1579. Langman, R. E. (1978). Rev. Physiol. Riochent. Pharinacol. 81, 1. Ledbetter, J. A , , Evans, R. , Good, R. A , , and Herzenberg, L. A. J. E x p . Med. 153, 310. Lee, N. , Ruddle, R. , Hedrick, S. , and Davis, M. D. J. Exp. Med. 160, 905. MacDonald, H . , Glasebrook, A. -C. (1982). Immunol. Reu. 68, 69. McIntyre, B. , and A h o n , J. P. (1984).

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Advances in Immunology, Vol. 38 by Frank J. Dlxon (Ed.)


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