Download e-book for kindle: Acute Myelogenous Leukemia by Farhad Ravandi, Francis Giles (auth.), Judith E. Karp MD

By Farhad Ravandi, Francis Giles (auth.), Judith E. Karp MD (eds.)

ISBN-10: 1588296210

ISBN-13: 9781588296214

ISBN-10: 1597453226

ISBN-13: 9781597453226

Acute Myelogenous Leukemia is a well timed compilation of latest options within the molecular pathogenesis and molecular remedy of acute myelogenous leukemia (AML). the focal point is on chosen severe molecular determinants of AML pathogenesis and pathophysiology and the exploitation of those elements by way of varied healing brokers and modalities. Bringing jointly new thoughts and findings within the easy and scientific technological know-how of AML, the ebook emphasizes the molecular foundation for brand spanking new remedies that stand to have the best capability influence at the scientific face of those ailments. The textual content presents insights into chosen novel options at the moment and prospectively being constructed, together with interruption of particular sign transduction pathways, modulation of gene expression, makes an attempt to reinstate differentiation, and immunomodulation. there's an emphasis all through at the bidirectional movement of information among the scientific and laboratory arenas, and either uncomplicated and medical scientists will make the most of this translational textual content.

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Many of the genetic changes that affect C/EBPa occur in separate AML subsets: flt3ITD is less common in CBF leukemias or in AMLs with CIEBPa mutations, CBF~-SMMHC is associated with FAB M4 cases, whereas CEBPA mutation is more common in FAB M2 AMLs, and AMLl-ETO and C/EBPa point mutations are found to be mutually exclusive in FAB M2 cases. Interestingly, t(8;21), inv(l6), and C/EBPa gene mutations are each considered to be favorable prognostic features of AML, further suggesting a mechanistic link among these leukemia subsets (110-112).

Blood 1997;89:3323-3329. 168. List AF, Kopecky KJ, Willman C, et al. Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood 2001;98:3212-3220. 169. Boesch D, Gaveriaux C, Jachez B, Pourtier-Manzanedo A, Bollinger P, Loor F. In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res 1991;51: 4226-4233. 170. Tidefelt U, Liliemark J, Gruber A, et al. P-Glycoprotein inhibitor valspodar (PSC 833;increases the intracellular concentrations of daunorubicin in vivo in patients with P-glycoprotein-positiveacute myeloid leukemia.

7. CIEBPa CCAAT/Enhancer binding protein a (C/EBPa) binds DNA via its C-terminal basic region leucine zipper (bZIP) motif and activates transcription via N-terminal transactivation domains (TADs) (95,96). The bZIP domain contains a basic region (BR) that contacts DNA and an adjacent leucine zipper (LZ) that mediates dimerization via its hydrophobic surface. CIEBPa and its family members are expressed in multiple tissues but are largely restricted to the granulocytic and monocytic lineages during hematopoiesis, with C/EBPa predominating in more immature cells (97,98).

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Acute Myelogenous Leukemia by Farhad Ravandi, Francis Giles (auth.), Judith E. Karp MD (eds.)


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